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Transcription profiling of human normal breast epithelium and stroma from reduction and I.D.C. cases

ABSTRACT: Histologically normal breast epithelium and stroma were laser capture microdissected from breast reduction specimens and from specimens of invasive ductal carcinoma. The objective of the study was to compare normal reduction tissues to tissues adjacent to I.D.C. to determine whether adjacent normal tissues contained expression profiles correlated with characteristics of the primary tumor and to identify markers of normal epithelium and stroma. Experiment Overall Design: common reference design. 66 samples replicated twice as dye swaps generating 132 arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Greg Finak

PROVIDER: E-GEOD-4823 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression signatures of morphologically normal breast tissue identify basal-like tumors.

Finak Greg G Sadekova Svetlana S Pepin Francois F Hallett Michael M Meterissian Sarkis S Halwani Fawaz F Khetani Karim K Souleimanova Margarita M Zabolotny Brent B Omeroglu Atilla A Park Morag M

Breast cancer research : BCR 20060101 5

<h4>Introduction</h4>The role of the cellular microenvironment in breast tumorigenesis has become an important research area. However, little is known about gene expression in histologically normal tissue adjacent to breast tumor, if this is influenced by the tumor, and how this compares with non-tumor-bearing breast tissue.<h4>Methods</h4>To address this, we have generated gene expression profiles of morphologically normal epithelial and stromal tissue, isolated using laser capture microdissect ...[more]

PMID: 17054791

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Comparison of normal breast epithelium and stroma from reduction and I.D.C. cases

Project description:Histologically normal breast epithelium and stroma were laser capture microdissected from breast reduction specimens and from specimens of invasive ductal carcinoma. The objective of the study was to compare normal reduction tissues to tissues adjacent to I.D.C. to determine whether adjacent normal tissues contained expression profiles correlated with characteristics of the primary tumor and to identify markers of normal epithelium and stroma. Keywords: disease state analysis

2006-10-20 | GSE4823 | GEO

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Homo sapiens

Project description:Comparison of normal breast epithelium and stroma from reduction and I.D.C. cases

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