Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard McEachin
PROVIDER: E-GEOD-48230 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Roca Hernan H Hernandez James J Weidner Savannah S McEachin Richard C RC Fuller David D Sud Sudha S Schumann Taibriana T Wilkinson John E JE Zaslavsky Alexander A Li Hangwen H Maher Christopher A CA Daignault-Newton Stephanie S Healy Patrick N PN Pienta Kenneth J KJ
PloS one 20131004 10
Cell plasticity regulated by the balance between the mesenchymal to epithelial transition (MET) and the opposite program, EMT, is critical in the metastatic cascade. Several transcription factors (TFs) are known to regulate EMT, though the mechanisms of MET remain unclear. We demonstrate a novel function of two TFs, OVOL1 and OVOL2, as critical inducers of MET in human cancers. Our findings indicate that the OVOL-TFs control MET through a regulatory feedback loop with EMT-inducing TF ZEB1, and t ...[more]