Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of rats' mRNA profile after knocking down PIWIL1 in embryonic cultured neurons.


ABSTRACT: We have demonstrated that PIWIL1 can regulate neuronal radial migration during corticogenesis. In order to explore the mechanism, we carried out high-throughtput sequencing (mRNA profile) to define downstream target of PIWIL during the process of neuronal migration. And we found the expression level of several microtubule-associated proteins decreased after downregulation of PIWIL1. Therefore, PIWIL1 plays an important role in neuronal migration by regulating the expression microtubule-associated proteins (such as Map1B, Map2, Tau) . Examine mRNA profile in two groups of primary cultured neurons with electroporation of control or RNAi plasmid.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Pingping Zhao 

PROVIDER: E-GEOD-48236 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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