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Identification of candidate FOXA2-regulated genes in the adult mouse uterus

ABSTRACT: To identify candidate genes regulated by forkhead transcription factor box A2 (FOXA2) in the uterus, control and Foxa2-deleted uteri were collected at day of pseudopregnancy (DOPP) 3.5 (DOPP 0.5= vaginal plug). Microarray analysis identified differentially expressed genes in the Foxa2-deleted as compared to control uteri that are candidiate FOXA2-regulated genes in the uterus. Whole uteri (control wild type n=4; Foxa2-deleted n=4) were analyzed for differences in their transcriptome using a mouse microarray.

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Spencer

PROVIDER: E-GEOD-48339 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus.

Filant Justyna J Lydon John P JP Spencer Thomas E TE

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130911 1

Uterine glands and their secretions are indispensable for endometrial function and fertility; however, the mechanisms regulating their development and function are not well understood. Forkhead transcription factor box A2 (FOXA2) is uniquely expressed in the glandular epithelial (GE) cells of the uterus, and conditional deletion of Foxa2 after birth impedes uterine gland development. An integrative approach was used here to define the FOXA2 cistrome in the murine uterus. Genome-wide mapping of F ...[more]

PMID: 24025729

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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