Unknown,Transcriptomics,Genomics,Proteomics

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Akt signalling leads to stem cell activation and promotes tumour development in epidermis.


ABSTRACT: A permantly active form of the oncogene Akt was expressed in the keratinocytes of the basal proliferative layer of the epidermis. Stem cells of the hair follicle expressing the cell surface marker CD34 were isolated. RNA form the CD34(+) and CD34(-) keratinocytes was extracted and and hybridized to Mouse Genome 430 2.0 Affymetrix arrays. Gene expression was compared between CD34(+) hair follicle stem cells and CD34(-) cells isolates from the back skin of K5-myrAkt transgenic mice.

ORGANISM(S): Mus musculus

SUBMITTER: Ramon Garcia-Escudero 

PROVIDER: E-GEOD-48522 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

Segrelles Carmen C   García-Escudero Ramón R   Garín Maria I MI   Aranda Juan F JF   Hernández Pilar P   Ariza José M JM   Santos Mirentxu M   Paramio Jesús M JM   Lorz Corina C  

Stem cells (Dayton, Ohio) 20140701 7


Hair follicle stem cells (HF-SCs) alternate between periods of quiescence and proliferation, to finally differentiate into all the cell types that constitute the hair follicle. Also, they have been recently identified as cells of origin in skin cancer. HF-SCs localize in a precise region of the hair follicle, the bulge, and molecular markers for this population have been established. Thus, HF-SCs are good model to study the potential role of oncogenic activations on SC physiology. Expression of  ...[more]

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