MicroRNA Expression based, Effects of Chronic Intermittent Ethanol paradigm on mouse brain
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Giorgio Gorini
PROVIDER: E-GEOD-48576 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Integration of miRNA and protein profiling reveals coordinated neuroadaptations in the alcohol-dependent mouse brain.
Gorini Giorgio G Nunez Yury O YO Mayfield R Dayne RD
PloS one 20131216 12
The molecular mechanisms underlying alcohol dependence involve different neurochemical systems and are brain region-dependent. Chronic Intermittent Ethanol (CIE) procedure, combined with a Two-Bottle Choice voluntary drinking paradigm, represents one of the best available animal models for alcohol dependence and relapse drinking. MicroRNAs, master regulators of the cellular transcriptome and proteome, can regulate their targets in a cooperative, combinatorial fashion, ensuring fine tuning and co ...[more]
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