Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: jinyong kim
PROVIDER: E-GEOD-48646 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of lipid research 20130923 12
Endotoxin tolerance allows macrophages to produce large quantities of proinflammatory cytokines immediately after their contact with lipopolysaccharides (LPSs), but prevents their further production after repeated exposure to LPSs. While this response is known to prevent overproduction of proinflammatory cytokines, the mechanism through which endotoxin tolerance is established has not been identified. In the current study, we demonstrate that sufficient production of geranylgeraniol (GGOH) in ma ...[more]