Unknown,Transcriptomics,Genomics,Proteomics

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Compare RNA profile between LPS+CPN and LPS+CPN+GGOH treated peritoneal macrophages


ABSTRACT: To find out genes regulated by geranylgeraniol (GGOH) treatment in peritoneal macrophage, we compared gene expression of cells treated with 200ng ml LPS and 250 micromolar compactin versus 200ng ml LPS, 250 micromolar compactin and 100micromolar GGOH. To find out upregulated or downregulated genes regulated by GGOH treatment in peritoneal macrophage (LPS+CPN treated cell).

ORGANISM(S): Mus musculus

SUBMITTER: jinyong kim 

PROVIDER: E-GEOD-48646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages.

Kim Jinyong J   Lee Joon No JN   Ye James J   Hao Rosy R   Debose-Boyd Russell R   Ye Jin J  

Journal of lipid research 20130923 12


Endotoxin tolerance allows macrophages to produce large quantities of proinflammatory cytokines immediately after their contact with lipopolysaccharides (LPSs), but prevents their further production after repeated exposure to LPSs. While this response is known to prevent overproduction of proinflammatory cytokines, the mechanism through which endotoxin tolerance is established has not been identified. In the current study, we demonstrate that sufficient production of geranylgeraniol (GGOH) in ma  ...[more]

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