Dataset Information
CC2_Navarre_14028srpoSlowhns-_IP_pHNStagged_antiHA
Ontology highlight
ABSTRACT:
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium
SUBMITTER: William Navarre
PROVIDER: E-GEOD-4881 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella.
Science (New York, N.Y.) 20060608 5784
Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired sequences can decrease fitness unless integrated into preexisting regulatory networks. We found that the histone-like nucleoid structuring protein (H-NS) selectively silences horizontally acquired genes by targeting sequences with GC content lower than the resident genome. Mutations in hns are lethal in Salmonella unless accompanied by compensatory mutations in other regulatory loci. Thus, H-NS provides a ...[more]
