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Expression data of PGR isoforms, PRA and PRB, regulated genes in differentiating human endometrial stromal cells

ABSTRACT: gene expression at 6h of differentiation of Human endometrial stromal cell expressing either or both of PRA and PRB Endogenous PGR expression is silenced with siRNA mediated knockdown. Then, cells are transduced with adenovirus exressing flag tagged PRA or flag tagged PRB. Human endometrial stromal cell expressing one or both isoforms are treated with differentiation cocktail for 6h.

ORGANISM(S): Homo sapiens

SUBMITTER: Milan Bagchi

PROVIDER: E-GEOD-48853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Roles of progesterone receptor A and B isoforms during human endometrial decidualization.

Kaya Hatice S HS Hantak Alison M AM Stubbs Lisa J LJ Taylor Robert N RN Bagchi Indrani C IC Bagchi Milan K MK

Molecular endocrinology (Baltimore, Md.) 20150415 6

Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, known as decidualization, which is a key step toward the establishment of pregnancy. Yet a long-standing unresolved issue in uterine biology is the precise roles played by the major PGR isoforms, PGR-A and PGR-B, during decidualization in the human. Our approach, expressing PGR-A and PGR-B individually after silencing endogenous PGRs in human endometrial stromal ...[more]

PMID: 25875046

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