Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Kenneth Poss
PROVIDER: E-GEOD-48914 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Fang Yi Y Gupta Vikas V Karra Ravi R Holdway Jennifer E JE Kikuchi Kazu K Poss Kenneth D KD
Proceedings of the National Academy of Sciences of the United States of America 20130730 33
Certain lower vertebrates like zebrafish activate proliferation of spared cardiomyocytes after cardiac injury to regenerate lost heart muscle. Here, we used translating ribosome affinity purification to profile translating RNAs in zebrafish cardiomyocytes during heart regeneration. We identified dynamic induction of several Jak1/Stat3 pathway members following trauma, events accompanied by cytokine production. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation ...[more]