Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of brain metastasis competent cell-derived exosomes


ABSTRACT: Objective of this work was to characterize the miRNA profile of exosomes isolated from brain-homing cell lines (MDA-MB-231BR, CTC1BMSM, and 70W) with their respective parental non-brain metastatic cell lines (MDA-MB-231P, CTC1P and MeWo). Exosomes derived from the six cell lines were isolated. Brain metastatic cell-derived exosomal miRNAs were compared with non brain metastatic cell lines (MDA-MB-231BR versus MDA-MB-231P, CTC1BMSM versus CTC1P, and 70W versus MeWo).

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Camacho 

PROVIDER: E-GEOD-48934 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA and protein profiling of brain metastasis competent cell-derived exosomes.

Camacho Laura L   Guerrero Paola P   Marchetti Dario D  

PloS one 20130916 9


Exosomes are small membrane vesicles released by most cell types including tumor cells. The intercellular exchange of proteins and genetic material via exosomes is a potentially effective approach for cell-to-cell communication and it may perform multiple functions aiding to tumor survival and metastasis. We investigated microRNA and protein profiles of brain metastatic (BM) versus non-brain metastatic (non-BM) cell-derived exosomes. We studied the cargo of exosomes isolated from brain-tropic 70  ...[more]

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