Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone


ABSTRACT: Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic subjects. This study sought to understand the pathophysiological mechanisms underlying the disparate cardiovascular effects of rosiglitazone and pioglitazone and yield knowledge as to the causative nature of rosiglitazone-associated cardiac hypertrophy. Total RNA obtained from mouse Apex from LDLr-/- mice treated with High Fat diet (HF) diet as control (n=6) or HF+Pio (n=5) or HF+Rosi (n=5).

ORGANISM(S): Mus musculus

SUBMITTER: Lars Verschuren 

PROVIDER: E-GEOD-48977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone.

Verschuren Lars L   Wielinga Peter Y PY   Kelder Thomas T   Radonjic Marijana M   Salic Kanita K   Kleemann Robert R   van Ommen Ben B   Kooistra Teake T  

BMC medical genomics 20140617


<h4>Background</h4>Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic subjects. This study sought to understand the pathophysiological and molecular mechanisms underlying the disparate cardiovascular effects of rosiglitazone and pioglitazone  ...[more]

Similar Datasets

2013-02-27 | E-GEOD-38688 | biostudies-arrayexpress
2014-06-30 | GSE48977 | GEO
2014-03-20 | E-GEOD-48261 | biostudies-arrayexpress
2006-11-08 | E-MEXP-715 | biostudies-arrayexpress
2009-12-05 | E-GEOD-14247 | biostudies-arrayexpress
| PRJNA90011 | ENA
2004-08-01 | GSE1458 | GEO
2007-10-09 | E-GEOD-1458 | biostudies-arrayexpress
2018-05-05 | GSE68604 | GEO
2018-05-05 | GSE68592 | GEO