Genome-wide profiling of the activity-dependent hippocampal transcriptome

ABSTRACT: Activity-dependent gene expression is central for sculpting neuronal connectivity in the brain. Despite the importance for synaptic plasticity, a comprehensive analysis of the temporal changes in the transcriptomic response to neuronal activity is lacking. In a genome wide survey we identified genes that were induced at 1, 4, 8, or 24 hours following neuronal activity in the hippocampus. 3 month old male mice were injected with kainic acid or isotonic saline solution. Animals were sacrificed by cervical luxation 1, 2, 4, 8, or 24 h after onset of the first seizure, and RNA was extracted from the hippocampal region.

ORGANISM(S): Mus musculus

SUBMITTER: Nils Blüthgen 

PROVIDER: E-GEOD-49030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress