Transcription profiling of human treated cord blood-derived human mast cells control and TGF-beta treated
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Zoltan Wiener
PROVIDER: E-GEOD-4906 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells.
Wiener Zoltan Z Kohalmi Barbara B Pocza Peter P Jeager Judit J Tolgyesi Gergely G Toth Sara S Gorbe Eva E Papp Zoltan Z Falus Andras A
The Journal of investigative dermatology 20061109 4
Many studies detect elevated numbers of mast cells in tumors, but it is still controversial whether they are beneficial or detrimental for tumor cells. Furthermore, many tumors, such as melanomas, produce large quantities of transforming growth factor (TGF)-beta and during tumorigenesis the apoptotic and growth-inhibitory effects of TGF-betas are lost. Based on these data we investigated the gene expression changes in TGF-betaI-treated human mast cells with DNA microarray and detected 45 differe ...[more]
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