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Expression data from neurospheres derived from the neocortex, striatum and subventricular zones of the adult mouse brain

ABSTRACT: Differential gene expression profiles of neurospheres derived from different regions of the adult brain. In this dataset, we include data on triplicated biological samples from each of the following brain regions: neocortex, striatum, and subventricular zone. We also include duplicated data on neurospheres derived from the dorsal and ventralforebrain neural tubes and one spinal cord of E14.5 mouse embryos for comparison. Fourteen samples were analyzed in total. To compare the expression profiles across the samples, Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform (total 41,170 probes) was used, and the data were analyzed using Silicon Genetics GeneSpring Software GX7.3.1. The data was normalized to median settings across the entire probe set and samples, and transcripts that are expressed across triplicated samples at levels two-fold or higher than the rest of the samples were considered as significantly enriched in particular biological samples. Comparisons between adult and embryonic samples also identified genes enriched in adult brain-derived samples.

ORGANISM(S): Mus musculus

SUBMITTER: Masato Nakafuku 

PROVIDER: E-GEOD-49194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Environmental impact on direct neuronal reprogramming in vivo in the adult brain.

Grande Andrew A   Sumiyoshi Kyoko K   López-Juárez Alejandro A   Howard Jennifer J   Sakthivel Bhuvaneswari B   Aronow Bruce B   Campbell Kenneth K   Nakafuku Masato M  

Nature communications 20130101

Direct reprogramming of non-neuronal cells to generate new neurons is a promising approach to repair damaged brains. Impact of the in vivo environment on neuronal reprogramming, however, is poorly understood. Here we show that regional differences and injury conditions have significant influence on the efficacy of reprogramming and subsequent survival of the newly generated neurons in the adult rodent brain. A combination of local exposure to growth factors and retrovirus-mediated overexpression  ...[more]

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