Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from the lungs of Scnn1b-Transgenic and wild-type mice


ABSTRACT: Airway mucus obstruction triggers macrophage activation and MMP12-dependent emphysema microarray expression profiling of lungs from Scnn1b-Tg mice to search for emphysema candidate genes

ORGANISM(S): Mus musculus

SUBMITTER: Raman Agrawal 

PROVIDER: E-GEOD-49373 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema.

Trojanek Joanna B JB   Cobos-Correa Amanda A   Diemer Stefanie S   Kormann Michael M   Schubert Susanne C SC   Zhou-Suckow Zhe Z   Agrawal Raman R   Duerr Julia J   Wagner Claudius J CJ   Schatterny Jolanthe J   Hirtz Stephanie S   Sommerburg Olaf O   Hartl Dominik D   Schultz Carsten C   Mall Marcus A MA  

American journal of respiratory cell and molecular biology 20141101 5


Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in β-epithelial Na(+) channel-transgenic (βENaC-Tg) mice demonstrated that airway surface dehydration, a key pathophysiological mechanism in cystic fibrosis (CF), caused emphysema in the absence of cigarette smoke exposure. However, the underlying mechanisms remain unknown. The aim of this study was to elucidate mechanisms of emphysema formation triggered by airway surface dehydration. We therefore used expressi  ...[more]

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