Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

The analysis of piRNA shows the function of Slicer activity of AGO3 in piRNA biogenesis.


ABSTRACT: Piwi-interacting RNAs (piRNAs) silence transposons in animal germ cells. In Drosophila, the reciprocal “Ping-Pong” cycle of piRNA-directed RNA cleavage, catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (AGO3) through their Slicer activity, is believed to expand the population of antisense piRNAs in response to transposon expression. Whether and how the Slicer activity of AGO3/Aub promotes the process of the secondary piRNA amplification remain unclear. Here we generated transgenic flies that could express AGO3 Slicer mutant forms to ellucidate the Slicer activity of AGO3. small-RNA libraries from 3 samples of D. mel. Ovaries.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Haidong Huang 

PROVIDER: E-GEOD-49436 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-06-30 | GSE49436 | GEO
2015-05-28 | E-GEOD-69293 | biostudies-arrayexpress
2015-08-31 | E-GEOD-71775 | biostudies-arrayexpress
2009-10-01 | E-GEOD-15137 | biostudies-arrayexpress
2015-05-28 | GSE69293 | GEO
2009-10-02 | GSE15137 | GEO
2020-06-25 | GSE153156 | GEO
2016-11-16 | GSE83698 | GEO
2011-08-15 | GSE30088 | GEO
2011-08-15 | E-GEOD-30088 | biostudies-arrayexpress