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Hypoxia transcriptome sequencing of blind mole rat (BMR, Spalax galili) and rat (Rattus norvegicus)

ABSTRACT: Deep sequencing of mRNA from Spalax galili and Rattus norvegicus Total RNAs were isolated from the brain of female BMRs under various oxygen concentrations (3%, 6%, 10%, 14%, and 21%) for 6 hours. We also got RNAs from the brain of rats under 6%, 10%, 14%, and 21% oxygen conditions.

ORGANISM(S): Nannospalax galili

SUBMITTER: Yulan Yang 

PROVIDER: E-GEOD-49485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Fang Xiaodong X   Nevo Eviatar E   Han Lijuan L   Levanon Erez Y EY   Zhao Jing J   Avivi Aaron A   Larkin Denis D   Jiang Xuanting X   Feranchuk Sergey S   Zhu Yabing Y   Fishman Alla A   Feng Yue Y   Sher Noa N   Xiong Zhiqiang Z   Hankeln Thomas T   Huang Zhiyong Z   Gorbunova Vera V   Zhang Lu L   Zhao Wei W   Wildman Derek E DE   Xiong Yingqi Y   Gudkov Andrei A   Zheng Qiumei Q   Rechavi Gideon G   Liu Sanyang S   Bazak Lily L   Chen Jie J   Knisbacher Binyamin A BA   Lu Yao Y   Shams Imad I   Gajda Krzysztof K   Farré Marta M   Kim Jaebum J   Lewin Harris A HA   Ma Jian J   Band Mark M   Bicker Anne A   Kranz Angela A   Mattheus Tobias T   Schmidt Hanno H   Seluanov Andrei A   Azpurua Jorge J   McGowen Michael R MR   Ben Jacob Eshel E   Li Kexin K   Peng Shaoliang S   Zhu Xiaoqian X   Liao Xiangke X   Li Shuaicheng S   Krogh Anders A   Zhou Xin X   Brodsky Leonid L   Wang Jun J   Wang Jun J  

Nature communications 20140603

The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground s  ...[more]

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