Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of pancreata, submandibular, and lacrimal glands from NOD-scid and C57Bl/6-scid mice to study the gene expression patterns of nonobese diabetic mice.


ABSTRACT: Prior to the onset of autoimmune destruction, type 1 diabetic patients and an animal model thereof, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormalities, but without the complications associated with inflammatory infiltrates, we examined genes expressed in autoimmune target tissues (pancreas, submandibular glands, and lacrimal glands) of NOD/scid mice and of autoimmune-resistant C57BL6/scid mice. Experiment Overall Design: Pancreata (6 weeks old mice), submandibular (9 and 15 weeks), and lacrimal glands (15 weeks) from individual NOD-scid and B6-scid mice were isolated for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Rodolfo Chaparro 

PROVIDER: E-GEOD-4953 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes.

Chaparro Rodolfo José RJ   Konigshofer Yves Y   Beilhack Georg F GF   Shizuru Judith A JA   McDevitt Hugh O HO   Chien Yueh-Hsiu YH  

Proceedings of the National Academy of Sciences of the United States of America 20060808 33


Before the onset of autoimmune destruction, type 1 diabetic patients and an animal model, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormalities, but without the complications associated with lymphocytic infiltrates, we examined genes expressed in autoimmune target tissues of NOD/severe combined immunodeficient (scid) mice and of autoimmune-resistant  ...[more]

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