Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marcel Kool
PROVIDER: E-GEOD-49822 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bender Sebastian S Tang Yujie Y Lindroth Anders M AM Hovestadt Volker V Jones David T W DT Kool Marcel M Zapatka Marc M Northcott Paul A PA Sturm Dominik D Wang Wei W Radlwimmer Bernhard B Højfeldt Jonas W JW Truffaux Nathalène N Castel David D Schubert Simone S Ryzhova Marina M Seker-Cin Huriye H Gronych Jan J Johann Pascal David PD Stark Sebastian S Meyer Jochen J Milde Till T Schuhmann Martin M Ebinger Martin M Monoranu Camelia-Maria CM Ponnuswami Anitha A Chen Spenser S Jones Chris C Witt Olaf O Collins V Peter VP von Deimling Andreas A Jabado Nada N Puget Stephanie S Grill Jacques J Helin Kristian K Korshunov Andrey A Lichter Peter P Monje Michelle M Plass Christoph C Cho Yoon-Jae YJ Pfister Stefan M SM
Cancer cell 20131031 5
Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global reduction of the repressive histone mark H3K27me3. We demonstrate that this is caused by aberrant recruitment of the PRC2 complex to K27M mutant H3.3 and enzymatic inhibition of the H3K27me3-establis ...[more]