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An atlas of active enhancers across human cell types and tissues

ABSTRACT: Sequencing of 5' ends of RNA molecules from control and exosome-depleted HeLa-S3 cells. CAGE library construction from RNA extracted from control and exosome-depleted cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Robin Andersson

PROVIDER: E-GEOD-49834 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An atlas of active enhancers across human cell types and tissues.

Andersson Robin R Gebhard Claudia C Miguel-Escalada Irene I Hoof Ilka I Bornholdt Jette J Boyd Mette M Chen Yun Y Zhao Xiaobei X Schmidl Christian C Suzuki Takahiro T Ntini Evgenia E Arner Erik E Valen Eivind E Li Kang K Schwarzfischer Lucia L Glatz Dagmar D Raithel Johanna J Lilje Berit B Rapin Nicolas N Bagger Frederik Otzen FO Jørgensen Mette M Andersen Peter Refsing PR Bertin Nicolas N Rackham Owen O Burroughs A Maxwell AM Baillie J Kenneth JK Ishizu Yuri Y Shimizu Yuri Y Furuhata Erina E Maeda Shiori S Negishi Yutaka Y Mungall Christopher J CJ Meehan Terrence F TF Lassmann Timo T Itoh Masayoshi M Kawaji Hideya H Kondo Naoto N Kawai Jun J Lennartsson Andreas A Daub Carsten O CO Heutink Peter P Hume David A DA Jensen Torben Heick TH Suzuki Harukazu H Hayashizaki Yoshihide Y Müller Ferenc F Forrest Alistair R R ARR Carninci Piero P Rehli Michael M Sandelin Albin A

Nature 20140301 7493

Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers. We show that enhancers share properties with CpG-poor messenger RNA promoters but prod ...[more]

PMID: 24670763

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