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Global Expression of Molecular Transporters in the Human Vaginal Tract

ABSTRACT: Pre-exposure chemoprophylaxis using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters in the human vaginal tract may play a pivotal role in determining drug disposition and, consequently, pharmacodynamic outcomes in these efforts. Little is known, however, on the expression of these transporters in vaginal tissues, representing a critical knowledge gap. Our study analyzed the genome-wide transcriptome in 44 vaginal tissue samples from 6 reproductive-age women undergoing gynecologic surgeries. The genome-wide transcriptome in 44 vaginal tissue samples from 6 reproductive-age women (20-56 years old) undergoing gynecologic surgeries was measured.

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Warden 

PROVIDER: E-GEOD-49892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global expression of molecular transporters in the human vaginal tract: implications for HIV chemoprophylaxis.

Gunawardana Manjula M   Mullen Madeline M   Moss John A JA   Pyles Richard B RB   Nusbaum Rebecca J RJ   Patel Jignesh J   Vincent Kathleen L KL   Wang Charles C   Guo Chao C   Yuan Yate-Ching YC   Warden Charles D CD   Baum Marc M MM  

PloS one 20131015 10

<h4>Background</h4>Pre-exposure chemoprophylaxis (PrECP) using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters in the human vaginal tract (VT) may play a pivotal role in determining drug disposition and, consequently, pharmacodynamic outcomes in these efforts. Little is known, however, on the expression of these transporters in vaginal tissues, representing a critical knowledge gap.<h4>Methodology/principal findings</h4  ...[more]

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