Unknown,Transcriptomics,Genomics,Proteomics

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The transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells [RNA-seq]


ABSTRACT: We demonstrate that transcription factor IRF4 is induced in a T cell receptor (TCR) affinity-dependent manner and functions as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulates the expression of key molecules required for aerobic glycolysis of effector T cells, and is essential for clonal expansion and maintenance of effector function of antigen-specific CD8+ T cells. Examination of gene expression profiles in six types of samples

ORGANISM(S): Mus musculus

SUBMITTER: Wei Shi 

PROVIDER: E-GEOD-49929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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