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Gene Level Expression Profiling: Activity dependent genes in the olfactory epithelium

ABSTRACT: Gene level analysis of RNA samples from mice olfactory epithelium Gene expression profiling in the olfactory epithelium was performed to obtain a better understanding of the processes mediating activity dependent gene regulation We analyzed total RNA from olfactory epithelium tissue from 3 mice at 5 days following unilateral naris occlusion (NO) using the Affymetrix Mouse Exon 1.0 ST Array, comparing unilateral and ipsilateral epithelia.

ORGANISM(S): Mus musculus

SUBMITTER: Timothy McClintock

PROVIDER: E-GEOD-49998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activity-dependent genes in mouse olfactory sensory neurons.

Fischl Adrian M AM Heron Paula M PM Stromberg Arnold J AJ McClintock Timothy S TS

Chemical senses 20140401 5

Activity-dependent survival of olfactory sensory neurons (OSNs) may allow animals to tune their olfactory systems to match their odor environment. Activity-dependent genes should play important roles in this process, motivating experiments to identify them. Both unilateral naris occlusion of mice for 6 days and genetic silencing of OSNs decreased S100A5, Lrrc3b, Kirrel2, Slc17a6, Rasgrp4, Pcp4l1, Plcxd3, and Kcnn2 while increasing Kirrel3. Naris occlusion also decreased Eml5, Ptprn, and Nphs1. O ...[more]

PMID: 24692514

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