Unknown,Transcriptomics,Genomics,Proteomics

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Unraveling the Sox4-orchestrated pro-B cell differentiation program: Intricate roles of the RAG and CK1e genes


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Xiaoping Sun 

PROVIDER: E-GEOD-50067 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1ε.

Mallampati Saradhi S   Sun Baohua B   Lu Yue Y   Ma Haiqing H   Gong Yun Y   Wang Donghai D   Lee Ju-Seog JS   Lin Kevin K   Sun Xiaoping X  

Blood 20140430 26


Commitment of hematopoietic stem cells to B lineage precursors and subsequent development of B lineage precursors into mature B cells is stringently controlled by stage-specific transcription factors. In this study, we used integrated genetic approaches and systematically determined the role of Sry-related high mobility group box (Sox) 4 and the underlying molecular mechanisms in early B-cell development. We found that Sox4 coordinates multilevel controls in the differentiation of early stage B  ...[more]

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