Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Xiaoping Sun
PROVIDER: E-GEOD-50067 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mallampati Saradhi S Sun Baohua B Lu Yue Y Ma Haiqing H Gong Yun Y Wang Donghai D Lee Ju-Seog JS Lin Kevin K Sun Xiaoping X
Blood 20140430 26
Commitment of hematopoietic stem cells to B lineage precursors and subsequent development of B lineage precursors into mature B cells is stringently controlled by stage-specific transcription factors. In this study, we used integrated genetic approaches and systematically determined the role of Sry-related high mobility group box (Sox) 4 and the underlying molecular mechanisms in early B-cell development. We found that Sox4 coordinates multilevel controls in the differentiation of early stage B ...[more]