Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide maps of Runx3 bound regions in splenic NK cells activated in vivo with IL-15

ABSTRACT: ChIP-seq was conducted using freshly isolated splenic WT NK cells from IL-15/Ra treated mice with anti-Runx3 antibody (Ab) and non-immune serum (NIS) as control. Runx3 and NIS IP from splenic NK cells of IL-15/Ra treated WT mice, isolated by negative selection using NK cell isolation kit (R&D) followed by sorting of NKp46+ cells.

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem 

PROVIDER: E-GEOD-50126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.

Levanon Ditsa D   Negreanu Varda V   Lotem Joseph J   Bone Karen Rae KR   Brenner Ori O   Leshkowitz Dena D   Groner Yoram Y  

Molecular and cellular biology 20140113 6

Natural killer cells belong to the family of innate lymphoid cells comprising the frontline defense against infected and transformed cells. Development and activation of natural killer cells is highly dependent on interleukin-15 signaling. However, very little is known about the transcription program driving this process. The transcription factor Runx3 is highly expressed in natural killer cells, but its function in these cells is largely unknown. We show that loss of Runx3 impaired interleukin-  ...[more]

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