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Links between the Oncoprotein YB-1 and Small Non-Coding RNAs in Breast Cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Cherie Blenkiron

PROVIDER: E-GEOD-50142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Links between the oncoprotein YB-1 and small non-coding RNAs in breast cancer.

Blenkiron Cherie C Hurley Daniel G DG Fitzgerald Sandra S Print Cristin G CG Lasham Annette A

PloS one 20131118 11

<h4>Background</h4>The nucleic acid-binding protein YB-1, a member of the cold-shock domain protein family, has been implicated in the progression of breast cancer and is associated with poor patient survival. YB-1 has sequence similarity to LIN28, another cold-shock protein family member, which has a role in the regulation of small noncoding RNAs (sncRNAs) including microRNAs (miRNAs). Therefore, to investigate whether there is an association between YB-1 and sncRNAs in breast cancer, we invest ...[more]

PMID: 24260353

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