Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Zizhen yao
PROVIDER: E-GEOD-50415 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
MacQuarrie Kyle L KL Yao Zizhen Z Fong Abraham P AP Diede Scott J SJ Rudzinski Erin R ER Hawkins Douglas S DS Tapscott Stephen J SJ
Molecular and cellular biology 20121210 4
Rhabdomyosarcoma is a pediatric tumor of skeletal muscle that expresses the myogenic basic helix-loop-helix protein MyoD but fails to undergo terminal differentiation. Prior work has determined that DNA binding by MyoD occurs in the tumor cells, but myogenic targets fail to activate. Using MyoD chromatin immunoprecipitation coupled to high-throughput sequencing and gene expression analysis in both primary human muscle cells and RD rhabdomyosarcoma cells, we demonstrate that MyoD binds in a simil ...[more]