Global gene expression analysis of canine cutaneous mast cell tumor

ABSTRACT: In the present study, canine mast cell tumor (MCT) transcriptome was characterized in order to identify a set of candidate genes potentially useful for MCT classification and prognosis prediction. Fifty-one canine MCT biopsies were enrolled in the study. Isolated and purified total RNAs were individually hybridized to the Agilent Canine V2 4x44k DNA microarray. The comparison of reference differentiated and undifferentiated MCT transcriptome revealed a total of 597 differentially expressed genes (450 up-regulated and 147 down-regulated). The functional analysis of this set of genes provided evidence that they were mainly involved in cell cycle, DNA replication, p53 signaling pathway, nucleotide excision repair and pyrimidine metabolism. Class prediction analysis identified 13 transcripts p

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Mery Giantin 

PROVIDER: E-GEOD-50433 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress