Applied Biosystems Human TaqMan Low Density Array (TLDA) in plasma samples from EOC cases and controls

ABSTRACT: Most (70%) epithelial ovarian cancers (EOCs) are diagnosed late. Non-invasive biomarkers that facilitate disease detection and predict outcome are needed. The microRNAs (miRNAs) represent a new class of biomarkers. This study was to identify and validate plasma miRNAs as biomarkers in EOC. We evaluated plasma samples of 360 EOC patients and 200 healthy controls from two institutions. All samples were grouped into screening, training and validation sets. We scanned the circulating plasma miRNAs by TaqMan low-density array in the screening set and identified/validated miRNA markers by real-time polymerase chain reaction assay in the training set. Receiver operating characteristic and logistic regression analyses established the diagnostic miRNA panel, which were confirmed in the validationse

ORGANISM(S): Homo sapiens

SUBMITTER: Lina Zhang 

PROVIDER: E-GEOD-50472 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress