Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptome of human osteosarcoma (HOS) cells induced by bisphenol A, S and AF

ABSTRACT: Whole genome expression data on transcriptome of human osteosarcoma (HOS) cells induced by bisfenol A (BPA), S (BPAS) and AF (BPAF) after short- (8 hours) and long-term (3 months) exposure at human-relevant (10 nM) concentrations. 8 experimental conditions, 4x2 design: 3 compounds (bisphenol A, S and AF) and a control, 2 exposure times (8 hours and 3 months). 3 replicates for each condition, 24 arrays in total.

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Juvan

PROVIDER: E-GEOD-50527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.

Fic A A Mlakar S Jurković SJ Juvan P P Mlakar V V Marc J J Dolenc M Sollner MS Broberg K K Mašič L Peterlin LP

Toxicology in vitro : an international journal published in association with BIBRA 20150422 5

The bisphenols AF (BPAF) and S (BPS) are structural analogs of the endocrine disruptor bisphenol A (BPA), and are used in common products as a replacement for BPA. To elucidate genome-wide gene expression responses, estrogen-dependent osteosarcoma cells were cultured with 10 nM BPA, BPAF, or BPS, for 8 h and 3 months. Genome-wide gene expression was analyzed using the Illumina Expression BeadChip. Three months exposure had significant effects on gene expression, particularly for BPS, followed by ...[more]

PMID: 25912373

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Dataset Information

Transcriptome of human osteosarcoma (HOS) cells induced by bisphenol A, S and AF

Publications

Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.

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