Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Craig Thompson
PROVIDER: E-GEOD-50539 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lu Chao C Venneti Sriram S Akalin Altuna A Fang Fang F Ward Patrick S PS Dematteo Raymond G RG Intlekofer Andrew M AM Chen Chong C Ye Jiangbin J Hameed Meera M Nafa Khedoudja K Agaram Narasimhan P NP Cross Justin R JR Khanin Raya R Mason Christopher E CE Healey John H JH Lowe Scott W SW Schwartz Gary K GK Melnick Ari A Thompson Craig B CB
Genes & development 20130901 18
More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation at CpG islands but not other genomic regions. Regions of CpG island hypermethylation were enriched for genes implicated in stem cell maintenance/differentiation and lineage specification. In murine 10 ...[more]