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RNA-Seq analysis of KLF3 knockout E14.5 TER119+ (erythroid) murine fetal liver cells

ABSTRACT: The aim of this study was to analyze the transcriptome of TER119+ fetal liver cells in the absence of the transcription factor KLF3 at murine embryonic day E14.5 Three wildtype (WT; Klf3+/+) and three knockout (KO; Klf3-/-) samples

ORGANISM(S): Mus musculus

SUBMITTER: Jon Burdach

PROVIDER: E-GEOD-50554 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor.

Mak Ka Sin KS Burdach Jon J Norton Laura J LJ Pearson Richard C M RC Crossley Merlin M Funnell Alister P W AP

Genome biology 20140430 4

<h4>Background</h4>Retroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized.<h4>Results</h4>Here we show that the zinc finger protein Krüppel-like Factor 3 (KLF3) specifically silences transcription from the ORR1A0 long terminal repeat in murine fetal and adul ...[more]

PMID: 24946810

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