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Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomics analysis of gene expression in normal and METTL3 or WTAP deficient Human 293T cells

ABSTRACT: RNA was isolated from and METTL3M-oM-

ORGANISM(S): Homo sapiens

SUBMITTER: sun baofa

PROVIDER: E-GEOD-50582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.

Ping Xiao-Li XL Sun Bao-Fa BF Wang Lu L Xiao Wen W Yang Xin X Wang Wen-Jia WJ Adhikari Samir S Shi Yue Y Lv Ying Y Chen Yu-Sheng YS Zhao Xu X Li Ang A Yang Ying Y Dahal Ujwal U Lou Xiao-Min XM Liu Xi X Huang Jun J Yuan Wei-Ping WP Zhu Xiao-Fan XF Cheng Tao T Zhao Yong-Liang YL Wang Xinquan X Rendtlew Danielsen Jannie M JM Liu Feng F Yang Yun-Gui YG

Cell research 20140110 2

The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the nature of this complex remains largely unknown. Here we report two new components of the human m6A methyltransferase complex, Wilms' tumor 1-associating protein (WTAP) and methyltransferase like 14 (METTL14). WTAP interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre- ...[more]

PMID: 24407421

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