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TEL-AML1 (ETV6-RUNX1) in B-cells and leukemia (part 4)

ABSTRACT: We identified directly and indirectly regulated target genes utilizing an inducible TEL-AML1 system derived from the murine pro B-cell line BA/F3 and a monoclonal antibody directed against TEL-AML1. By integration of promoter binding identified with ChIP-on-chip, gene expression and protein output through microarray technology and stable labelling of amino acids in cell culture (SILAC), we identified directly and indirectly regulated targets of the TEL-AML1 fusion protein. Bound promoter regions of immunoprecipitated TEL-AML1 associated genes were first compared to input material and enrichment was calculated. 3 independent replicates were performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Pablo Landgraf

PROVIDER: E-GEOD-50733 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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