Tgif1 regulates quiescence and self-renewal signaling pathways of hematopoietic stem cells (HSCs)
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ABSTRACT: In this study we demonstrate that Tgif1 has a role in HSCs maintenance, self-renewal and quiescence. RNA sequencing data of LSK cells (HSCs enriched cell population) from Tgif1-/- and wild type mice implicates that multiple pathways involved in HSC quiescence and self-renewal are disturbed in Tgif1 deficient mice. RNA expression profiles of wild type (WT) and Tgif1-/- LSK cells were generated by RNA sequencing, in triplicate, using Illumina HiSeq 2000.
ORGANISM(S): Mus musculus
SUBMITTER: Yan Guo
PROVIDER: E-GEOD-50739 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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