Unknown,Transcriptomics,Genomics,Proteomics

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Prevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA


ABSTRACT: Silencing HoxA1 in vivo by intraductal delivery of nanoparticle-formulated siRNA reduced mammary tumor incidence by 75% , reduced cell proliferation, and prevented loss of ER and PR expression. 8 week wild type FVB mouse whole mammary gland and 8week to 20 week transgenic FVB C3(1)-SV40Tag mouse whole mammary gland

ORGANISM(S): Mus musculus

SUBMITTER: Hu Li 

PROVIDER: E-GEOD-50813 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.

Brock Amy A   Krause Silva S   Li Hu H   Kowalski Marek M   Goldberg Michael S MS   Collins James J JJ   Ingber Donald E DE  

Science translational medicine 20140101 217


With advances in screening, the incidence of detection of premalignant breast lesions has increased in recent decades; however, treatment options remain limited to surveillance or surgical removal by lumpectomy or mastectomy. We hypothesized that disease progression could be blocked by RNA interference (RNAi) therapy and set out to develop a targeted therapeutic delivery strategy. Using computational gene network modeling, we identified HoxA1 as a putative driver of early mammary cancer progress  ...[more]

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