Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hu Li
PROVIDER: E-GEOD-50813 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Science translational medicine 20140101 217
With advances in screening, the incidence of detection of premalignant breast lesions has increased in recent decades; however, treatment options remain limited to surveillance or surgical removal by lumpectomy or mastectomy. We hypothesized that disease progression could be blocked by RNA interference (RNAi) therapy and set out to develop a targeted therapeutic delivery strategy. Using computational gene network modeling, we identified HoxA1 as a putative driver of early mammary cancer progress ...[more]