Expression Data For BRD4 Inhibition
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Amish Patel
PROVIDER: E-GEOD-50865 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction.
Patel Amish J AJ Liao Chung-Ping CP Chen Zhiguo Z Liu Chiachi C Wang Yong Y Le Lu Q LQ
Cell reports 20131227 1
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas that develop sporadically or in neurofibromatosis type 1 (NF1) patients. There is no effective treatment for MPNSTs and they are typically fatal. To gain insights into MPNST pathogenesis, we utilized an MPNST mouse model that allowed us to study the evolution of these tumors at the transcriptome level. Strikingly, in MPNSTs we found upregulation of a chromatin regulator, Brd4, and show that BRD4 inhibition profoundl ...[more]
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