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Next generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy

ABSTRACT: Early chemotherapy for advanced/metastatic non-castration resistant prostate cancer (PCa) may improve overall patient survival. We studied the safety, tolerability and early efficacy of up-front docetaxel chemotherapy and androgen deprivation therapy (ADT) versus ADT alone for patients with newly-diagnosed advanced/metastatic PCa. As proof of concept, we undertook in vivo gene expression profiling by next generation RNA sequencing (RNA-Seq). Tumour biposies from 6 patients were taken before and after treatment with combined ADT and docetaxcel for 6 weeks

ORGANISM(S): Homo sapiens

SUBMITTER: Ian Sudbery

PROVIDER: E-GEOD-51005 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.

Rajan Prabhakar P Stockley Jacqueline J Sudbery Ian M IM Fleming Janis T JT Hedley Ann A Kalna Gabriela G Sims David D Ponting Chris P CP Heger Andreas A Robson Craig N CN McMenemin Rhona M RM Pedley Ian D ID Leung Hing Y HY

BMC cancer 20141218

<h4>Background</h4>Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential prognostic biomarkers. We performed in vivo transcriptome profiling of pre- and post-treatment prostatic biopsies from patients with advanced hormone-naive prostate cancer treated with docetaxel chemotherapy and androgen deprivation therapy (ADT) with an aim to identify t ...[more]

PMID: 25519703

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