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Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Danio rerio

SUBMITTER: Mark Ibberson

PROVIDER: E-GEOD-51014 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways.

Crippa Stefania S Nemir Mohamed M Ounzain Samir S Ibberson Mark M Berthonneche Corinne C Sarre Alexandre A Boisset Gaëlle G Maison Damien D Harshman Keith K Xenarios Ioannis I Diviani Dario D Schorderet Daniel D Pedrazzini Thierry T

Cardiovascular research 20160207 1

<h4>Aims</h4>The adult mammalian heart has poor regenerative capacity. In contrast, the zebrafish heart retains a robust capacity for regeneration into adulthood. These distinct responses are consequences of a differential utilization of evolutionary-conserved gene regulatory networks in the damaged heart. To systematically identify miRNA-dependent networks controlling cardiac repair following injury, we performed comparative gene and miRNA profiling of the cardiac transcriptome in adult mice an ...[more]

PMID: 26857418

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Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways

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