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Expression data from 8-10 week old WT mice maintained in room air or exposed to hyperoxia (FiO2>95%) for 48 hrs

ABSTRACT: To detect sex-specific differences in gene expression in a model of hyperoxic lung injury in adult C56BL/6J mice. In this dataset, we include the expression data obtained from lungs from 8-10 week old male and female WT C57BL/6J mice exposed to hyperoxia for 48 hours amd room air controls.These data were used to determine differences in transcriptome between male and female mice after hyperoxia exposure 12 total samples were analyzed. We generated the following pairwise comparisons: 5 comparisons (M/F: male/female, A/O: air/oxygen): 1) M_O - M_A,  2) F_O - F_A, 3) M_O - F_O, 4) M_A - F_A, 5) (M_O - M_A) - (F_O - F_A). Genes with an FDR≤5% and a fold-change ≥1.4 were selected.

ORGANISM(S): Mus musculus

SUBMITTER: Krithika Lingappan

PROVIDER: E-GEOD-51039 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression.

Lingappan Krithika K Srinivasan Chandra C Jiang Weiwu W Wang Lihua L Couroucli Xanthi I XI Moorthy Bhagavatula B

PloS one 20140708 7

Exposure to high concentration of oxygen (hyperoxia) leads to lung injury in experimental animal models and plays a role in the pathogenesis of diseases such as Acute Respiratory Distress Syndrome (ARDS) and Bronchopulmonary dysplasia (BPD) in humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. The major goal of this study was to characterize the changes in the pulmonary transcriptome following hyperoxia exposure and ...[more]

PMID: 25003466

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