Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Atsuhiro Taguchi
PROVIDER: E-GEOD-51054 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Taguchi Atsuhiro A Kaku Yusuke Y Ohmori Tomoko T Sharmin Sazia S Ogawa Minetaro M Sasaki Hiroshi H Nishinakamura Ryuichi R
Cell stem cell 20131212 1
Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental origins of the metanephric mesenchyme (MM), which generates most kidney components. Unexpectedly, we find that posteriorly located T(+) MM precursors are developmentally distinct from Osr1(+) ureteric bud progenitors during the postgastrulation stage, and we identify phasic Wnt stimulation and stage-specific growth fact ...[more]