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Transcription profiling of human primary and secondary glioblastomas

ABSTRACT: Gene expression data of primary and secondary glioblastoma subgroups. Experiment Overall Design: Total RNA was extracted from eighty-three glioblastoma biopsies in total. Probes were synthesized using the commercial Affymetrix kits and hybridized onto U133A Arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Cho-Lea Tso

PROVIDER: E-GEOD-5107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Primary glioblastomas express mesenchymal stem-like properties.

Tso Cho-Lea CL Shintaku Peter P Chen James J Liu Qinghai Q Liu Jason J Chen Zugen Z Yoshimoto Koji K Mischel Paul S PS Cloughesy Timothy F TF Liau Linda M LM Nelson Stanley F SF

Molecular cancer research : MCR 20060901 9

Glioblastoma is the most common and aggressive primary brain cancer. Recent isolation and characterization of brain tumor-initiating cells supports the concept that transformed neural stem cells may seed glioblastoma. We previously identified a wide array of mesenchymal tissue transcripts overexpressed in a broad set of primary glioblastoma (de novo) tumors but not in secondary glioblastoma (derived from lower-grade) tumors, low-grade astrocytomas, or normal brain tissues. Here, we extend this o ...[more]

PMID: 16966431

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