Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Davide Calebiro
PROVIDER: E-GEOD-5115 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Calebiro Davide D de Filippis Tiziana T Lucchi Simona S Martinez Fernando F Porazzi Patrizia P Trivellato Roberta R Locati Massimo M Beck-Peccoz Paolo P Persani Luca L
Molecular endocrinology (Baltimore, Md.) 20060803 12
A global gene expression profiling of TSH stimulation on differentiated (FRTL5) and partially dedifferentiated [FRT/TSHR (TSH receptor)] rat thyroid cells was performed. A total of 123 TSH-regulated genes (95 newly described) were identified in FRTL5, whereas no significant transcriptional modifications were seen in FRT/TSHR cells. Because regulatory subunit IIbeta (RIIbeta) of protein kinase A (PKA), a key element downstream of cAMP, was expressed in FRTL5 but not in cAMP-refractory FRT/TSHR ce ...[more]