Expression data from control and mutant TIFIACaMKCreERT2
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Grzegorz Kreiner
PROVIDER: E-GEOD-51240 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:We have investigated the p53-dependent stress response in medium spiny neurons (MSNs) that degenerate in Huntington’s disease. To induce p53 signaling cascade, we have genetically inactivated by the Cre/loxP system the essential RNA polymerase I (Pol I) transcription factor TIF-IA, leading to stabilization of p53 and induction of p53-dependent apoptosis. In the present study, we selectively ablated the TIF-IA gene in MSNs by crossing TIF-IAflox/flox mice, homozygous for the floxed TIF-IA allele with transgenic mice expressing the Cre recombinase under the control of the D1 dopamine receptor (D1R) promoter.
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