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Genes regulated by TAZ in lung cancer cell lines

ABSTRACT: To investigate the roles of TAZ in lung cancer cell proliferation, we compared the expression profiles of A549 and H441 lung adenocarcinoma cell lines transfected with control siRNA and siTAZ. We collected RNA from A549 and H441 cell lines transfected with control siRNA and siTAZ.

ORGANISM(S): Homo sapiens

SUBMITTER: Akira Saito 

PROVIDER: E-GEOD-51270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.

Noguchi Satoshi S   Saito Akira A   Horie Masafumi M   Mikami Yu Y   Suzuki Hiroshi I HI   Morishita Yasuyuki Y   Ohshima Mitsuhiro M   Abiko Yoshimitsu Y   Mattsson Johanna Sofia Margareta JS   König Helena H   Lohr Miriam M   Edlund Karolina K   Botling Johan J   Micke Patrick P   Nagase Takahide T  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140620 17

<h4>Purpose</h4>TAZ, also known as WWTR1, has recently been suggested as an oncogene in non-small cell lung cancer (NSCLC). We investigated the clinical relevance of TAZ expression and its functional role in NSCLC tumorigenesis.<h4>Experimental design</h4>We characterized TAZ at the DNA (n=192), mRNA (n=196), and protein levels (n=345) in an NSCLC patient cohort. Gene expression analysis was complemented by a meta-analysis of public datasets (n=1,382). The effects of TAZ on cell proliferation an  ...[more]

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