Unknown,Transcriptomics,Genomics,Proteomics

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Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor


ABSTRACT: Platelets contain abundant miRNAs, however, the biogenesis pathway of miRNAs in anucleate platelets is unclear. Platelet-rich plasma was diluted in washing buffer and the platelet suspension was centrifuged to isolated pure platelets.Finally, platelets were recovered in suspension buffer at the concentration of 4–5×10^8 platelets/ml. Aliquots of the platelet suspensions were activated in the presence of 2.5 mM CaCl2 with 0ng/ml or 1 ng/ml thrombopoietin (TPO)

ORGANISM(S): Homo sapiens

SUBMITTER: Zhen Zhou 

PROVIDER: E-GEOD-51453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor.

Pan Yi Y   Liang Hongwei H   Liu Huan H   Li Donghai D   Chen Xi X   Li Limin L   Zhang Chen-Yu CY   Zen Ke K  

Journal of immunology (Baltimore, Md. : 1950) 20131204 1


Platelets play a significant role in atherosclerosis, stroke, and asthma through active interaction with neutrophils, monocytes, and vascular endothelial cells. The mechanism underlying these intercellular interactions, however, is incompletely understood. In this study, we report that platelets can remotely modulate vascular endothelial cell apoptosis through releasing microRNA-223 (miR-223)-containing microvesicles (MVs). First, platelets expressed abundant miRNAs, and miR-223 had the highest  ...[more]

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