Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Zhen Zhou
PROVIDER: E-GEOD-51453 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pan Yi Y Liang Hongwei H Liu Huan H Li Donghai D Chen Xi X Li Limin L Zhang Chen-Yu CY Zen Ke K
Journal of immunology (Baltimore, Md. : 1950) 20131204 1
Platelets play a significant role in atherosclerosis, stroke, and asthma through active interaction with neutrophils, monocytes, and vascular endothelial cells. The mechanism underlying these intercellular interactions, however, is incompletely understood. In this study, we report that platelets can remotely modulate vascular endothelial cell apoptosis through releasing microRNA-223 (miR-223)-containing microvesicles (MVs). First, platelets expressed abundant miRNAs, and miR-223 had the highest ...[more]