Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lora Hooper
PROVIDER: E-GEOD-5156 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cash Heather L HL Whitham Cecilia V CV Behrendt Cassie L CL Hooper Lora V LV
Science (New York, N.Y.) 20060801 5790
The mammalian intestine harbors complex societies of beneficial bacteria that are maintained in the lumen with minimal penetration of mucosal surfaces. Microbial colonization of germ-free mice triggers epithelial expression of RegIIIgamma, a secreted C-type lectin. RegIIIgamma binds intestinal bacteria but lacks the complement recruitment domains present in other microbe-binding mammalian C-type lectins. We show that RegIIIgamma and its human counterpart, HIP/PAP, are directly antimicrobial prot ...[more]