Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stuart Tangye
PROVIDER: E-GEOD-51587 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Berglund Lucinda J LJ Avery Danielle T DT Ma Cindy S CS Moens Leen L Deenick Elissa K EK Bustamante Jacinta J Boisson-Dupuis Stephanie S Wong Melanie M Adelstein Stephen S Arkwright Peter D PD Bacchetta Rosa R Bezrodnik Liliana L Dadi Harjit H Roifman Chaim M CM Fulcher David A DA Ziegler John B JB Smart Joanne M JM Kobayashi Masao M Picard Capucine C Durandy Anne A Cook Matthew C MC Casanova Jean-Laurent JL Uzel Gulbu G Tangye Stuart G SG
Blood 20131024 24
B-cell responses are guided by the integration of signals through the B-cell receptor (BCR), CD40, and cytokine receptors. The common γ chain (γc)-binding cytokine interleukin (IL)-21 drives humoral immune responses via STAT3-dependent induction of transcription factors required for plasma cell generation. We investigated additional mechanisms by which IL-21/STAT3 signaling modulates human B-cell responses by studying patients with STAT3 mutations. IL-21 strongly induced CD25 (IL-2Rα) in normal, ...[more]