Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Eric Paquet
PROVIDER: E-GEOD-51643 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boucherat Olivier O Nadeau Valérie V Bérubé-Simard Félix-Antoine FA Charron Jean J Jeannotte Lucie L
Development (Cambridge, England) 20140801 16
The mammalian genome contains two ERK/MAP kinase genes, Mek1 and Mek2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. In order to define the function of the ERK/MAPK pathway in the lung development in mice, we performed tissue-specific deletions of Mek1 function on a Mek2 null background. Inactivation of both Mek genes in mesenchyme resulted in several phenotypes, including giant omphalocele, kyphosis, pulmonary hypoplasia, defective tracheal cartilage and death ...[more]